Photoimmunotechnology as a powerful biological tool for molecular-based elimination of target cells and microbes, including bacteria, fungi and viruses

Tadayuki Iwase, Kimihiro Ito, Takashi Nishimura, Kei Miyakawa, Akihide Ryo, Hisataka Kobayashi, Makoto Mitsunaga

Published: 2023-10-03 DOI: 10.1038/s41596-023-00874-z

Photoimmunotechnology

Antimicrobial strategy

Monoclonal antibody

Phthalocyanine derivative

Targeted elimination

AI 解读

Generation of mouse–human chimeric embryos

Genome-wide quantification of transcription factor binding at single-DNA-molecule resolution using methyl-transferase footprinting

Generation of CRISPR–Cas9-mediated genetic knockout human intestinal tissue–derived enteroid lines by lentivirus transduction and single-cell cloning

A puromycin-dependent activity-based sensing probe for histochemical staining of hydrogen peroxide in cells and animal tissues

Decoding personal biotic and abiotic airborne exposome

A clinically relevant model of focal embolic cerebral ischemia by thrombus and thrombolysis in rhesus monkeys

Bioengineering human intestinal mucosal grafts using patient-derived organoids, fibroblasts and scaffolds

Biomimetic tail-to-head terpene cyclizations using the resorcin[4]arene capsule catalyst

Neuroscience robotics for controlled induction and real-time assessment of hallucinations

Scanorama: integrating large and diverse single-cell transcriptomic datasets

Single-cell RNA sequencing (scRNA-seq)（单细胞RNA测序）

Data integration（数据集成）

Heterogeneity（异质性）

查看全部

Sections

Figures

References

Introduction
Materials
Procedure
Troubleshooting
Timing
Anticipated results
- PIAS
- PIT
Conclusions
- Reporting summary
Acknowledgements

Levy, S. B. & Marshall, B. Antibacterial resistance worldwide: causes, challenges and responses. Nat. Med. 10, S122–S129 (2004).
Antimicrobial Resistance Collaborators. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. Lancet 99, 629–655 (2022).
Chambers, H. F. & Deleo, F. R. Waves of resistance: Staphylococcus aureus in the antibiotic era. Nat. Rev. Microbiol. 7, 629–641 (2009).
Kluytmans, J., van Belkum, A. & Verbrugh, H. Nasal carriage of Staphylococcus aureus: epidemiology, underlying mechanisms, and associated risks. Clin. Microbiol. Rev. 10, 505–520 (1997).
Iwase, T. et al. Staphylococcus epidermidis Esp inhibits Staphylococcus aureus biofilm formation and nasal colonization. Nature 465, 346–349 (2010).
Guan, W. J. et al. China medical treatment expert group for COVID-19. Clinical characteristics of coronavirus disease 2019 in China. N. Engl. J. Med. 382, 1708–1720 (2020).
Laxminarayan, R. et al. Access to effective antimicrobials: a worldwide challenge. Lancet 387, 168–175 (2016).
Coates, A., Hu, Y., Bax, R. & Page, C. The future challenges facing the development of new antimicrobial drugs. Nat. Rev. Drug Discov. 1, 895–910 (2002).
Mitsunaga, M. et al. Cancer cell-selective in vivo near infrared photoimmunotherapy targeting specific membrane molecules. Nat. Med. 17, 1685–1691 (2011).
Mitsunaga, M. et al. Antimicrobial strategy for targeted elimination of different microbes, including bacterial, fungal and viral pathogens. Commun. Biol. 5, 647 (2022).
Mitsunaga, M. et al. A flexible target-specific anti-infection therapeutic platform that can be applied to different microbial species. Preprint at bioRxiv http://doi.org/10.1101/2020.04.20.049791 (2020).
Sato, K. et al. Photoinduced ligand release from a silicon phthalocyanine dye conjugated with monoclonal antibodies: a mechanism of cancer cell cytotoxicity after near-infrared photoimmuno therapy. ACS Cent. Sci. 4, 1559–1569 (2018).
Kato, T. et al. Electron donors rather than reactive oxygen species needed for therapeutic photochemical reaction of near-infrared photoimmunotherapy. ACS Pharmacol. Transl. Sci. 4, 1689–1701 (2021).
Hatayama, Y. et al. Development of a monoclonal antibody targeting HTLV-1 envelope gp46 glycoprotein and its application to near-infrared photoimmuno-antimicrobial strategy. Viruses 14, 2153 (2022).
Yasui, H. et al. Near infrared photo-antimicrobial targeting therapy for Candida albicans. Adv. Ther. 4, 2000221 (2021).
Huang, M., Shen, A., Ding, J. & Geng, M. Molecularly targeted cancer therapy: some lessons from the past decade. Trends Pharmacol. Sci. 35, 41–50 (2014).
Scott, A., Wolchok, J. & Old, L. Antibody therapy of cancer. Nat. Rev. Cancer 12, 278–287 (2012).
Loibl, S. & Gianni, L. HER2-positive breast cancer. Lancet 389, 2415–2429 (2017).
Hughes, J. P., Rees, S., Kalindjian, S. B. & Philpott, K. L. Principles of early drug discovery. Br. J. Pharmacol. 162, 1239–1249 (2011).
Arora, A. & Scholar, E. M. Role of tyrosine kinase inhibitors in cancer therapy. J. Pharmacol. Exp. Ther. 315, 971–979 (2005).
Matsuyama, S. et al. Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells. Proc. Natl Acad. Sci. USA 117, 7001–7003 (2020).
Kokai-Kun, J. F. The cotton rat as a model for Staphylococcus aureus nasal colonization in humans: cotton rat S. aureus nasal colonization model. Methods Mol. Biol. 431, 241–254 (2008).
Mitsunaga, M. et al. Immediate in vivo target-specific cancer cell death after near infrared photoimmunotherapy. BMC Cancer 12, 345 (2012).
Nakajima, T., Sano, K., Mitsunaga, M., Choyke, P. L. & Kobayashi, H. Real-time monitoring of in vivo acute necrotic cancer cell death induced by near infrared photoimmunotherapy using fluorescence lifetime imaging. Cancer Res. 72, 4622–4628 (2012).
Sano, K., Mitsunaga, M., Nakajima, T., Choyke, P. L. & Kobayashi, H. Acute cytotoxic effects of photoimmunotherapy assessed by 18F-fluorodeoxyglucose (FDG) PET. J. Nucl. Med. 54, 770–775 (2013).
Kosaka, N. et al. Semiquantitative assessment of the microdistribution of fluorescence- labeled monoclonal antibody in small peritoneal disseminations of ovarian cancer. Cancer Sci. 101, 820–825 (2010).
Kosaka, N. et al. Microdistribution of fluorescently-labeled monoclonal antibody in a peritoneal dissemination model of ovarian cancer. Proc. Spie. 7576, 7576041–7576049 (2010).
Mitsunaga, M., Nakajima, T., Sano, K., Choyke, P. L. & Kobayashi, H. Near-infrared theranostic photoimmunotherapy (PIT): repeated exposure of light enhances the effect of immunoconjugate. Bioconjugate Chem. 23, 604–609 (2012).

Photoimmunotechnology as a powerful biological tool for molecular-based elimination of target cells and microbes, including bacteria, fungi and viruses

Supplementary information

Supplementary Information

Reporting Summary

推荐阅读